4/5/2023 0 Comments Supertab 11sdThe results showed that formulations containing both of super-disintegrants and effervescent bases had better disintegration time compare to other formulations. Mixture of powders and orally dispersible tablets passed all tests. Disintegration time of the groups 1, 2 and 3 were in the range of 16-70, 47-72 and 12-35 seconds respectively. Thickness, hardness, wetting time, friability and content uniformity of formulations were in the range of 3.36-3.84 mm, 33.25-38.03 N, 19-37 seconds, 0.31-0.42 % and 96.44-99.02 % respectively. The angle of repose and compressibility index of formulations were in the range of 24.65-29.08 and 5.02-9.01 % respectively. Tablets evaluated by friability, thickness, hardness, weight variation, drug content, content uniformity, disintegration time, wetting time, dissolution and moisture uptake tests. Proposed by DesignExpert software, the optimum formulations were selected in each category and the tablets were produced by direct compression method. Group 1 consist of super-disintegrating bases, group 2 consist of effervescent bases and group 3 consist of super-disintegrating and effervescent bases together. This product is easy to use for babies, geriatrics and people who have difficulty in swallowing.ģ1 formulations were designed in 3 categories via Design-Expert software version 7. Among the three groups, F9 Formulation as the best formulation and showed maximum dissolution rate with drug release.ĭesign, formulation and physicochemical evaluation of dimenhydrinate 25 mg oral tablets that disintegrate in oral cavity in a proper time. The prepared batches of tablets were evaluated for hardness, weight variation, friability, disintegration time and in-vitro dissolution profile and found satisfactory. Orally disintegrating tablets prepared by direct compression and using Supertab11SD, Avicel PH 102, Crospovidone, Ac-Di-Sol, Sodium starch glycolate, Aspartame, Magnesium stearate were prepared and evaluated for the precompression parameters such as bulk density, compressibility, angle of repose etc. Hence the main objective of the study was to formulate oral disintegrating tablets of Zolmitriptan to achieve a better dissolution rate and further improving the bioavailability of the drug. Zolmitriptan, the absolute bioavailability is only approximately 40% due to extensive hepatic first pass metabolism (CYP1A2-mediated). Zolmitriptan is a selective serotonin receptor agonist. It is suited for tablets undergoing high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to minimize side effect and make it more cost effective. There is an increasing demand for more patient compliant dosage form and a novel method is the development orally disintegrating tablets which dissolve or disintegrates instantly on the patient tongue or buccal mucosa. Orally disintegrating tablets (ODTs) are getting popularity over conventional tablets due totheir convenience in administration and suitability for patients having dysphagia (difficulty in swallowing).
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